Green chemistry metrics as guiding tools in the synthesis of 2-substituted benzimidazole N-oxides: improvement in sustainability by a simple work-up modification.

POLITANO, FABRIZIO; LEADBEATER, NICHOLAS E.

Conferencia; 6th Green and Sustainable Chemistry Conference; 2021

Elsevier

Recently, we have generated a library of over 40 novel benzimidazole N-oxidecompounds in a two-step one-pot protocol. This class of compound shows biologicalactivity against some neglected tropical diseases (NTDs), making approaches to theirsynthesis particularly pertinent. Our methodology offer a greener alternative than thosepreviously reported as it uses only water and ethanol as solvents. Moreover, with asimple modification in the work-up, we could avoid liquid-liquid extraction and columnchromatography; product isolation being achieved by pH-dependent precipitation. Herepresent an assessment of our protocol using different simple sustainability metrics, suchas E-factor, CHEM21, EcoScale, Dozn, and Green Star.